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Gene FLT3
Variant K429E
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 K429E lies within the extracellular domain of the Flt3 protein (UniProt.org). K429E is predicted to confer a gain of function to the Flt3 protein, as demonstrated by transformation of cells in culture compared to wild-type Flt3 (PMID: 30651561).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 K429E

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Transcript NM_004119.2
gDNA chr13:g.28037209T>C
cDNA c.1285A>G
Protein p.K429E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28037209T>C c.1285A>G p.K429E RefSeq GRCh38/hg38
NM_004119 chr13:g.28037209T>C c.1285A>G p.K429E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 K429E hematologic cancer resistant Crenolanib Preclinical - Cell culture Actionable In a preclinical study, Crenolanib (CP-868596) did not decrease proliferation of transformed cells expressing FLT3 K429E in culture (PMID: 30651561). 30651561