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|Protein Effect||loss of function|
|Gene Variant Descriptions||HRAS inact mut indicates that the variant results in failure to activate HRAS downstream signaling. However, the specific amino acid change has not been identified.|
|Associated Drug Resistance|
|Category Variants Paths||
HRAS mutant HRAS inact mut
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|HRAS inact mut||thyroid cancer||sensitive||Dactolisib||Preclinical||Actionable||In a preclinical study, BEZ235 inhibited growth of thyroid cancer cells harboring an HRAS pathway activating mutation in cell culture (PMID: 21831957).||21831957|