Gene Variant Detail

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Gene ERBB4
Variant E57K
Impact List missense
Protein Effect no effect
Gene Variant Descriptions ERBB4 E57K lies within the extracellular domain of the Erbb4 protein (UniProt.org). E57K results in autophosphorylation, cellular proliferation and colony formation similar to wild-type Erbb4 in culture (PMID: 30975989).
Associated Drug Resistance

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Transcript NM_005235
gDNA chr2:g.212124817C>T
cDNA c.169G>A
Protein p.E57K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017003579 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_005246376 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003581 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003581 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_006712364 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_005246376 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_005246377 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_005246377 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003581 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003579 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003580 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_005246376 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
NM_005235 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003578 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
NM_001042599 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
NM_001042599 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003580 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
NM_005235 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003577 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003579 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003577 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_006712364 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
NM_001042599 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003577 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003580 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003578 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_006712364 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_017003578 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
NM_005235 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38
XM_005246377 chr2:g.212124817C>T c.169G>A p.E57K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ERBB4 E57K no effect
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References