Gene Variant Detail

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Gene SRC
Variant K298M
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions SRC K298M lies within the protein kinase domain of the Src protein (UniProt.org). K298M results in an open protein conformation in an in vitro assay (PMID: 31287657), and results in decreased proliferation and kinase activity in cell culture (PMID: 16415104, PMID: 18698806).
Associated Drug Resistance

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Transcript NM_198291
gDNA chr20:g.37400148_37400149delAAinsTG
cDNA c.893_894delAAinsTG
Protein p.K298M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011529013 chr20:g.37400148_37400149delAAinsTG c.893_894delAAinsTG p.K298M RefSeq GRCh38/hg38
NM_198291 chr20:g.37400148_37400149delAAinsTG c.893_894delAAinsTG p.K298M RefSeq GRCh38/hg38
NM_005417 chr20:g.37400148_37400149delAAinsTG c.893_894delAAinsTG p.K298M RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
SRC K298M loss of function