Gene Variant Detail

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Gene SRC
Variant W263A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions SRC W263A does not lie within any known functional domain of the Src protein (UniProt.org). W263A results in an open conformation of the kinase domain, but results in reduced catalytic activity of the protein in an in vitro assay (PMID: 31287657), and therefore, is predicted to lead to a loss of Src protein function.
Associated Drug Resistance

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Transcript NM_198291
gDNA chr20:g.37397782_37397783delTGinsGC
cDNA c.787_788delTGinsGC
Protein p.W263A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011529013 chr20:g.37397782_37397783delTGinsGC c.787_788delTGinsGC p.W263A RefSeq GRCh38/hg38
NM_005417 chr20:g.37397782_37397783delTGinsGC c.787_788delTGinsGC p.W263A RefSeq GRCh38/hg38
NM_198291 chr20:g.37397782_37397783delTGinsGC c.787_788delTGinsGC p.W263A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Protein Effect Treatment Approaches
SRC W263A loss of function - predicted
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References