Gene Variant Detail

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Gene PIK3CA
Variant T1025I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA T1025I lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). T1025I has been identified in sequencing studies (PMID: 25680416, PMID: 22949056, PMID: 21726664), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Feb 2020).
Associated Drug Resistance

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Transcript NM_006218
gDNA chr3:g.179234231C>T
cDNA c.3074C>T
Protein p.T1025I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179234231C>T c.3074C>T p.T1025I RefSeq GRCh38/hg38
XM_006713658 chr3:g.179234231C>T c.3074C>T p.T1025I RefSeq GRCh38/hg38
XM_011512894 chr3:g.179234231C>T c.3074C>T p.T1025I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PIK3CA T1025I unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References