Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Protein Effect||loss of function - predicted|
|Gene Variant Descriptions||APC L852* results in a premature truncation of the Apc protein at amino acid 852 of 2843 (UniProt.org). L852* has not been characterized, however, Apc truncation mutants downstream of L852 are inactivating (PMID: 18199528) and therefore, is predicted to lead to a loss of Apc protein function.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|APC L852*||colorectal cancer||predicted - resistant||G007-LK||Preclinical||Actionable||In a preclinical study, G007-LK treatment did not alter gene expression pattern or affect growth in intestinal organoids established from mouse models of colorectal cancer driven by APC L850* (corresponding to L852* in human), and had no effect on tumor cell growth and differentiation in APC L850* mouse models (PMID: 31337618).||31337618|