Gene Variant Detail

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Gene BRAF
Variant G464R
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF G464R (also reported as G463R) lies within the protein kinase domain of the Braf protein (UniProt.org). G464R results in increased Braf kinase activity, increased downstream Erk signaling (PMID: 15046639), and induces cell proliferation and cell viability in culture (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G464X BRAF G464R

BRAF mutant BRAF act mut BRAF G464R

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Transcript NM_004333.5
gDNA chr7:g.140781618C>T
cDNA c.1390G>A
Protein p.G464R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140781618C>T c.1390G>A p.G464R RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781618C>T c.1390G>A p.G464R RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781618C>T c.1390G>A p.G464R RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781618C>T c.1390G>A p.G464R RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G464R Advanced Solid Tumor resistant Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, Zelboraf (vemurafenib) did not inhibit MEK and ERK activation in transformed cells over expressing the constitutively dimerized BRAF G464R (PMID: 26343582). 26343582