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Gene PIK3CA
Variant T1052K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA T1052K does not lie within any known functional domains of the Pik3ca protein (UniProt.org). T1052K has been identified in the scientific literature (PMID: 31410178, PMID: 21725289, PMID: 27672108), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon21 PIK3CA T1052K

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Transcript NM_006218.4
gDNA chr3:g.179234312C>A
cDNA c.3155C>A
Protein p.T1052K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
NM_006218 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179234312C>A c.3155C>A p.T1052K RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA R88L PIK3CA E453del PIK3CA T1052K PTEN loss PTEN mut endometrial carcinoma sensitive Copanlisib Phase I Actionable In a Phase I clinical trial, an endometrial carcinoma patient harboring PIK3CA T1052K, R88L, and E453del, as well as a PTEN mutation and loss of PTEN protein expression demonstrated a complete response to treatment with Aliqopa (copanlisib) (PMID: 27672108). 27672108