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|Gene Variant Descriptions||CALR E380fs results in a change in the amino acid sequence of the Calr protein beginning at aa 380 of 417, likely resulting in premature truncation of the functional protein (UniProt.org). E380fs has been identified in the scientific literature (PMID: 30805227), but has not been biochemically characterized and therefore, its effect on Calr protein function is unknown (PubMed, Dec 2019).|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Protein Effect||Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|