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|Gene Variant Descriptions||CALR E380Gfs*50 indicates a shift in the reading frame starting at amino acid 380 and terminating 50 residues downstream, resulting in premature truncation of the functional protein and extension of the 417aa Calr protein length by 13 amino acids (UniProt.org). E380Gfs*50 has been identified in the scientific literature (PMID: 30805227), but has not been biochemically characterized and therefore, its effect on Calr protein function is unknown (PubMed, Dec 2019).|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Protein Effect||Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|