Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene BRAF
Variant T310I
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF T310I does not lie within any known functional domains of the Braf protein (UniProt.org). T310I is predicted to lead to a gain of Braf protein function as indicated by intermediate increase of Erk phosphorylation in culture, and is associated with resistance to Raf inhibitors (PMID: 31158244).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF act mut BRAF T310I

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_004333.6
gDNA chr7:g.140800413G>A
cDNA c.929C>T
Protein p.T310I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378471.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012559 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_005250045 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012558 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_004333 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF T310I breast cancer predicted - resistant Dabrafenib Preclinical Actionable In a preclinical study, Tafinlar (dabrafenib) treatment resulted in increased Erk phosphorylation in breast cancer cells expressing BRAF T310I in culture (PMID: 31158244). 31158244