Gene Variant Detail

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Gene BRAF
Variant V600Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF V600Q (previously reported as V599Q) lies within the activation segment and the protein kinase domain of the Braf protein (PMID: 15035987). V600Q has been identified in the scientific literature (PMID: 28848703), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Nov 2022).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF V600X BRAF V600Q

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Transcript NM_004333.5
gDNA chr7:g.140753336_140753337delGTinsCA
cDNA c.1798_1799delGTinsCA
Protein p.V600Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.5 chr7:g.140753336_140753337delGTinsCA c.1798_1799delGTinsCA p.V600Q RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753336_140753337delACinsTG c.1798_1799delGTinsCA p.V600Q RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753336_140753337delGTinsCA c.1798_1799delGTinsCA p.V600Q RefSeq GRCh38/hg38
NM_004333 chr7:g.140753336_140753337delACinsTG c.1798_1799delGTinsCA p.V600Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References