Gene Variant Detail

Gene AKT1
Variant W80A
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions AKT1 W80A lies within the PH domain of the Akt1 protein (UniProt.org). Akt1 demonstrates phosphorylation and downstream signaling similar to wild-type Akt1 in cell culture (PMID: 25856301), however, is associated with Akt inhibitor resistance (PMID: 18669636, PMID: 25856301).
Associated Drug Resistance Y

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Transcript NM_001014432
gDNA chr14:g.104776707_104776708delCAinsGC
cDNA c.238_239delTGinsGC
Protein p.W80A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005267401 chr14:g.104776707_104776708delCAinsGC c.238_239delTGinsGC p.W80A RefSeq GRCh38/hg38
NM_005163 chr14:g.104776707_104776708delCAinsGC c.238_239delTGinsGC p.W80A RefSeq GRCh38/hg38
XM_017021077 chr14:g.104776707_104776708delCAinsGC c.238_239delTGinsGC p.W80A RefSeq GRCh38/hg38
XM_017021078 chr14:g.104776707_104776708delCAinsGC c.238_239delTGinsGC p.W80A RefSeq GRCh38/hg38
NM_001014432 chr14:g.104776707_104776708delCAinsGC c.238_239delTGinsGC p.W80A RefSeq GRCh38/hg38
NM_001014431 chr14:g.104776707_104776708delCAinsGC c.238_239delTGinsGC p.W80A RefSeq GRCh38/hg38
XM_017021076 chr14:g.104776707_104776708delCAinsGC c.238_239delTGinsGC p.W80A RefSeq GRCh38/hg38
XM_017021075 chr14:g.104776707_104776708delCAinsGC c.238_239delTGinsGC p.W80A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
AKT1 W80A no effect - predicted Akt Inhibitor (Pan) Akt1 Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AKT1 W80A Advanced Solid Tumor resistant MK2206 Preclinical - Cell culture Actionable In a preclinical study, transformed mouse adipocytes expressing human Akt1 W80A were resistant to the AKT inhibitor, MK-2206 (PMID: 25856301). 25856301
AKT1 W80A breast cancer resistant MK2206 Preclinical Actionable In a preclinical study, breast cancer cells expressing AKT1 W80A were resistant to MK2206 in culture, resulting in repression of induced cell death when compared to wild-type AKT1 (PMID: 25551293). 25551293