Gene Variant Detail

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Gene KDR
Variant Y105C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KDR (VEGFR2) Y105C lies within the Ig-like C2-type domain 1 of the Kdr (Vegfr2) protein (UniProt.org). Y105C has been identified in sequencing studies (PMID: 27149842, PMID: 25344691), but has not been biochemically characterized and therefore, its effect on Kdr (Vegfr2) protein function is unknown (PubMed, Feb 2021).
Associated Drug Resistance

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Transcript NM_002253.3
gDNA chr4:g.55118648T>C
cDNA c.314A>G
Protein p.Y105C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002253 chr4:g.55118648T>C c.314A>G p.Y105C RefSeq GRCh38/hg38
NM_002253.3 chr4:g.55118648T>C c.314A>G p.Y105C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
KDR Y105C unknown