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Gene | KDR |
Variant | Y105C |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | KDR (VEGFR2) Y105C lies within the Ig-like C2-type domain 1 of the Kdr (Vegfr2) protein (UniProt.org). Y105C has been identified in sequencing studies (PMID: 27149842, PMID: 25344691), but has not been biochemically characterized and therefore, its effect on Kdr (Vegfr2) protein function is unknown (PubMed, Feb 2021). |
Associated Drug Resistance |
Transcript | NM_002253.3 |
gDNA | chr4:g.55118648T>C |
cDNA | c.314A>G |
Protein | p.Y105C |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002253 | chr4:g.55118648T>C | c.314A>G | p.Y105C | RefSeq | GRCh38/hg38 |
NM_002253.3 | chr4:g.55118648T>C | c.314A>G | p.Y105C | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
KDR Y105C | unknown |