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|Gene Variant Descriptions||PIK3CA Q546X indicates any Pik3ca missense mutation which results in the glutamine (Q) at amino acid 546 being replaced by a different amino acid.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA Q546X||endometrial adenocarcinoma||no benefit||Copanlisib||Case Reports/Case Series||Actionable||In a Phase II (NRG-GY008) trial, Aliqopa (copanlisib) was well tolerated but demonstrated limited efficacy, resulted in 1 stable disease and 1 progressive disease in 2 patients with endometrioid adenocarcinoma harboring PIK3CA Q546 mutations, and stable disease in a patient with serous endometrial adenocarcinoma harboring a PIK3CA Q546 mutation (PMID: 31934607).||31934607|
|Molecular Profile||Protein Effect||Treatment Approaches|