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|Gene Variant Descriptions||KDR (VEGFR2) V297I lies within the Ig-like C2-type domain 3 of the Kdr (Vegfr2) protein (UniProt.org). The functional effect of V297I is conflicting, as it had no effect on Kdr (Vegfr2) phosphorylation levels in cell culture in one study (PMID: 21712447), however in another study, was suggested to have reduced binding to Vegf in cell culture (PMID: 17707181), and therefore, its effect on Kdr protein function is unknown.|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|