Gene Variant Detail

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Gene TP53
Variant R181L
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 R181L lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). R181L results in cell cycle arrest similar to wild-type Tp53, however, leads to a selective loss of DNA binding and activation of a downstream promoter, IGF-BP3 box B, and fails to induce apoptosis in culture (PMID: 31483066, PMID: 20471942, PMID: 8756654).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 inact mut TP53 R181L

TP53 mutant TP53 exon5 TP53 R181L

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Transcript NM_000546.6
gDNA chr17:g.7675070C>A
cDNA c.542G>T
Protein p.R181L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675070C>A c.542G>T p.R181L RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 R181L lung adenocarcinoma sensitive Doxorubicin + Nutlin-3a Preclinical - Cell culture Actionable In a preclinical study, a lung adenocarcinoma cell line expressing TP53 R181L demonstrated enhanced sensitivity to Adriamycin (doxorubicin) treatment when combined with Nutlin-3, and induced apoptosis in culture (PMID: 31483066). 31483066