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|Gene Variant Descriptions||RET L881V lies within the protein kinase domain of the Ret protein (UniProt.org). L881V has been demonstrated to confer resistance to some RET inhibitors in the context of KIF5B-RET in cultured cells (PMID: 31118272), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2020).|
|Associated Drug Resistance||Y|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Protein Effect||Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|