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|Variant||ETV6 - TYK2|
|Protein Effect||gain of function - predicted|
|Gene Variant Descriptions||ETV6-TYK2 (also reported as TEL-TYK2) results from the fusion of ETV6 and TYK2 (PMID: 10706877), which leads to constitutive Stat1/3/5 activation and is transforming in cell culture (PMID: 10706877), and therefore, is predicted to confer a gain of protein function.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ETV6 - TYK2||gain of function - predicted|