Gene Variant Detail

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Gene KMT2A FOXO4
Variant KMT2A - FOXO4
Impact List fusion
Protein Effect gain of function
Gene Variant Descriptions KMT2A-FOXO4 (also referred to as MLL-AFX) results from the fusion of KMT2A and FOXO4 (PMID: 9010221), which leads to enhanced self-renewal of myeloid cells in culture and induces leukemia in mouse models (PMID: 12192052). KMT2A-FOXO4 has been identified in acute leukemias (PMID: 12192052, PMID: 28701730).
Associated Drug Resistance

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
KMT2A - FOXO4 gain of function