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|Variant||KMT2A - FOXO4|
|Protein Effect||gain of function|
|Gene Variant Descriptions||KMT2A-FOXO4 (also referred to as MLL-AFX) results from the fusion of KMT2A and FOXO4 (PMID: 9010221), which leads to enhanced self-renewal of myeloid cells in culture and induces leukemia in mouse models (PMID: 12192052). KMT2A-FOXO4 has been identified in acute leukemias (PMID: 12192052, PMID: 28701730).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|
|KMT2A - FOXO4||gain of function|