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Gene RET
Variant S891A
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET S891A lies within the protein kinase domain of the Ret protein (UniProt.org). S891A results in constitutive phosphorylation of Ret and downstream activation of Stat3 signaling through Src, Jak1, and Jak2-dependent pathways in cell culture (PMID: 15753368).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET S891A

RET mutant RET S891X RET S891A

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Transcript NM_020975.6
gDNA chr10:g.43120144T>G
cDNA c.2671T>G
Protein p.S891A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_020975 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43123675T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43126731T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43123675T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_020630 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120144T>G c.2671T>G p.S891A RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET S891A Advanced Solid Tumor sensitive Sorafenib Preclinical Actionable In a preclinical study, Nexavar (sorafenib) inhibited RET phosphorylation in cells expressing RET S891A in culture (PMID: 17664273). 17664273
RET S891A Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited phosphorylation of Ret in transformed human cells expressing RET S891A in culture (PMID: 23526464). 23526464
RET S891A Advanced Solid Tumor sensitive Vandetanib Preclinical Actionable In a preclinical study, Caprelsa (vandetanib) inhibited Ret autophosphorylation in transformed cells expressing RET S891A in culture (PMID: 15184865). 15184865
RET S891A thyroid gland medullary carcinoma predicted - sensitive Vandetanib Case Reports/Case Series Actionable In a clinical case study, neoadjuvant Caprelsa (vandetanib) treatment resulted in a 65% decrease in the thyroid mass and cervical lymph nodes allowing for surgical resection in a pediatric patient with medullary thyroid carcinoma harboring RET S891A (PMID: 38207224). 38207224