Gene Variant Detail

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Gene ERBB2
Variant T216S
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ERBB2 (HER2) T216S lies within the extracellular domain of the Erbb2 (Her2) protein (PMID: 22908275). T216S is predicted to confer a gain of function to the Erbb2 (Her2) protein as demonstrated by increased kinase activity (PMID: 22908275).
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39710088A>T
cDNA c.646A>T
Protein p.T216S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004448 chr17:g.39710088A>T c.646A>T p.T216S RefSeq GRCh38/hg38
NM_001289937 chr17:g.39710088A>T c.646A>T p.T216S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ERBB2 T216S gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References