Gene Variant Detail

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Gene ERBB2
Variant R896C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ERBB2 (HER2) R896C lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). R896C results in constitutive phosphorylation of Erbb2 (Her2), increased downstream signaling, and is transforming in cell culture (PMID: 23220880).
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39725363C>T
cDNA c.2686C>T
Protein p.R896C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004448 chr17:g.39725363C>T c.2686C>T p.R896C RefSeq GRCh38/hg38
NM_001289937 chr17:g.39725363C>T c.2686C>T p.R896C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 R896C breast cancer sensitive Lapatinib Preclinical Actionable In a preclinical study, transformed human breast cell lines expressing ERBB2 R896C reverted to normal morphology in culture upon Tykerb (lapatinib) treatment (PMID: 23220880). 23220880
ERBB2 R896C breast cancer sensitive Neratinib Preclinical Actionable In a preclinical study, transformed human breast cell lines expressing ERBB2 (HER2) R896C reverted to normal morphology in culture upon Nerlynx (neratinib) treatment (PMID: 23220880). 23220880
ERBB2 R896C breast cancer sensitive Trastuzumab Preclinical Actionable In a preclinical study, transformed human breast cell lines expressing ERBB2 R896C reverted to normal morphology in culture upon Herceptin (trastuzumab) treatment (PMID: 23220880). 23220880
Molecular Profile Protein Effect Treatment Approaches
ERBB2 R896C gain of function HER inhibitor (Pan) HER2 Inhibitor