Gene Variant Detail

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Gene ERBB2
Variant S779_P780insVGS
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions ERBB2 (HER2) S779_P780insVGS results in the insertion of three amino acids in the protein kinase domain of the Erbb2 (Her2) protein between amino acids 779 and 780 (UniProt.org). S779_P780insVGS has not been characterized, however other exon 20 insertions are activating thus, S779_P780insVGS is predicted to lead to gain of Erbb2 (Her2) function (PMID: 16843263, PMID: 17311002, PMID: 23220880).
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39724755_39724756insGTAGGTAGC
cDNA c.2337_2338insGTAGGTAGC
Protein p.V777_S779dupVGS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004448 chr17:g.39724755_39724756insGTAGGTAGC c.2337_2338insGTAGGTAGC p.V777_S779dupVGS RefSeq GRCh38/hg38
NM_001289937 chr17:g.39724755_39724756insGTAGGTAGC c.2337_2338insGTAGGTAGC p.V777_S779dupVGS RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
ERBB2 S779_P780insVGS gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor