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Gene NRAS
Variant G13C
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G13C is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G13C has not been characterized, but can be predicted to confer a loss of function to the Nras protein based on the effects of KRAS G13C and HRAS G13C, which result in increased GTP-bound Ras and activation of downstream signaling (PMID: 25705018, PMID: 21850009).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G13C

NRAS mutant NRAS exon2 NRAS G13X NRAS G13C

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Transcript NM_002524.5
gDNA chr1:g.114716124C>A
cDNA c.37G>T
Protein p.G13C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114716124C>A c.37G>T p.G13C RefSeq GRCh38/hg38
NM_002524 chr1:g.114716124C>A c.37G>T p.G13C RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716124C>A c.37G>T p.G13C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References