Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Gene Variant Descriptions||DDR2 T654I is a gatekeeper mutation that lies within the protein kinase domain of the Ddr2 protein (UniProt.org). T654I has been associated with secondary drug resistance (PMID: 24296828), but has not been biochemically characterized and therefore, its effect on Ddr2 protein function is unknown (PubMed, Jun 2020).|
|Associated Drug Resistance||Y|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|DDR2 L239R DDR2 T654I||lung squamous cell carcinoma||predicted - resistant||Dasatinib||Preclinical - Cell culture||Actionable||In a preclinical study, DDR2 T654I was identified as an acquired mutation in lung squamous cell carcinoma cells harboring DDR2 L239R that became resistant to Sprycel (dasatinib) in culture (PMID: 24296828).||24296828|