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Gene DDR2
Variant T654M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DDR2 T654M lies within the protein kinase domain of the Ddr2 protein (UniProt.org). T654M has been demonstrated to occur as a "gatekeeper" mutation and is associated with secondary drug resistance (PMID: 22328973), but has not been biochemically characterized, and therefore, its effect on Ddr2 protein function is unknown (PubMed, Jul 2020).
Associated Drug Resistance Y

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Transcript NM_001014796
gDNA chr1:g.162775756_162775757delCTinsTG
cDNA c.1961_1962delCTinsTG
Protein p.T654M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011509586 chr1:g.162775756_162775757delCTinsTG c.1961_1962delCTinsTG p.T654M RefSeq GRCh38/hg38
XM_011509587 chr1:g.162775756_162775757delCTinsTG c.1961_1962delCTinsTG p.T654M RefSeq GRCh38/hg38
NM_006182 chr1:g.162775756_162775757delCTinsTG c.1961_1962delCTinsTG p.T654M RefSeq GRCh38/hg38
NM_001014796 chr1:g.162775756_162775757delCTinsTG c.1961_1962delCTinsTG p.T654M RefSeq GRCh38/hg38
XM_006711344 chr1:g.162775756_162775757delCTinsTG c.1961_1962delCTinsTG p.T654M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
DDR2 I638F DDR2 T654M lung squamous cell carcinoma decreased response Dasatinib Preclinical Actionable In a preclinical study, expression of DDR2 T654M in lung squamous cell cancer cells harboring DDR2 I638F resulted in decreased sensitivity to Sprycel (dasatinib) in culture (PMID: 22328973). 22328973
DDR2 L239R DDR2 T654M lung squamous cell carcinoma decreased response Dasatinib Preclinical Actionable In a preclinical study, expression of DDR2 T654M in lung squamous cell cancer cells harboring DDR2 L239R resulted in decreased sensitivity to Sprycel (dasatinib) in culture (PMID: 22328973). 22328973
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
DDR2 mutant lung squamous cell carcinoma sensitive Dasatinib Preclinical Actionable In a preclinical study, lung squamous cell cancer cells harboring DDR2 mutations demonstrated sensitivity to Sprycel (dasatinib) in culture (PMID: 22328973). 22328973
Molecular Profile Protein Effect Treatment Approaches
DDR2 T654M unknown
DDR2 I638F DDR2 T654M
DDR2 L239R DDR2 T654M