Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Protein Effect||gain of function|
|Gene Variant Descriptions||DDR2 act mut indicates that this variant results in a gain of function in the Ddr2 protein. However, the specific amino acid change has not been identified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|DDR2 act mut||lung non-small cell carcinoma||sensitive||Lucitanib||Preclinical||Actionable||In a preclinical study, Lucitanib (E-3810) decreased DDR2 phosphorylation, and inhibited proliferation and induced apoptosis in lung squamous cell carcinoma cells harboring a DDR2 activating mutation in culture (PMID: 24696502).||24696502|