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Gene FGFR3
Variant S756P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 S756P lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). S756P has not been characterized in the scientific literature and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Oct 2023).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 S756P

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Transcript NM_000142.5
gDNA chr4:g.1806926T>C
cDNA c.2266T>C
Protein p.S756P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000142.4 chr4:g.1806926T>C c.2266T>C p.S756P RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1806926T>C c.2266T>C p.S756P RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1806926T>C c.2266T>C p.S756P RefSeq GRCh38/hg38
XM_006713873 chr4:g.1806926T>C c.2266T>C p.S756P RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806926T>C c.2266T>C p.S756P RefSeq GRCh38/hg38
NM_000142 chr4:g.1806926T>C c.2266T>C p.S756P RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1806926T>C c.2266T>C p.S756P RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1806926T>C c.2266T>C p.S756P RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 S756P lung non-small cell carcinoma no benefit AZD4547 Case Reports/Case Series Actionable In a Phase II trial (NLMT), AZD4547 treatment did not result in a confirmed response or durable clinical benefit in a patient with non-small cell lung cancer harboring FGFR3 S758P (corresponds to S756P in the canonical isoform (PMID: 32669708, NCT02664935). 32669708