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Gene FGFR3
Variant R421Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 R421Q lies within the cytoplasmic domain of the Fgfr3 protein (UniProt.org). R421Q has been identified in sequencing studies (PMID: 27701467), but has not been biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Mar 2023).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 R421Q

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Transcript NM_000142.4
gDNA chr4:g.1804516G>A
cDNA c.1262G>A
Protein p.R421Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000142.4 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
XM_011513420.1 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
XM_011513420 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
NM_001354809.1 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
XM_006713873 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
XM_011513422 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
NM_000142 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38
XM_006713872 chr4:g.1804516G>A c.1262G>A p.R421Q RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References