Gene Variant Detail

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Gene HRAS
Variant K117N
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS K117N lies within the GTP binding domain of the Hras protein (UniProt.org). K117N results in decreased nucleotide binding affinity and activation of Hras in culture (PMID: 24247240).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS K117N

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Transcript NM_005343.4
gDNA chr11:g.533552C>G
cDNA c.351G>C
Protein p.K117N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795 chr11:g.533552C>G c.351G>C p.K117N RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533552C>G c.351G>C p.K117N RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533552C>G c.351G>C p.K117N RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533552C>G c.351G>C p.K117N RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533552C>G c.351G>C p.K117N RefSeq GRCh38/hg38
NM_005343 chr11:g.533552C>G c.351G>C p.K117N RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533552C>G c.351G>C p.K117N RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533552C>G c.351G>C p.K117N RefSeq GRCh38/hg38
NM_001130442 chr11:g.533552C>G c.351G>C p.K117N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS K117N head and neck squamous cell carcinoma predicted - sensitive Tipifarnib Preclinical - Pdx Actionable In a preclinical study, a head and neck squamous cell carcinoma patient-derived xenograft (PDX) model harboring HRAS K117N was sensitive to treatment with Zarnestra (tipifarnib), demonstrating inhibition of tumor growth, decreased cell proliferation, and reduced Erk activity (PMID: 32727882). 32727882