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Gene | HRAS |
Variant | K117N |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | HRAS K117N lies within the GTP binding domain of the Hras protein (UniProt.org). K117N results in decreased nucleotide binding affinity and activation of Hras in culture (PMID: 24247240). |
Associated Drug Resistance |
Transcript | NM_005343.3 |
gDNA | chr11:g.533552C>G |
cDNA | c.351G>C |
Protein | p.K117N |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_176795.4 | chr11:g.533552C>G | c.351G>C | p.K117N | RefSeq | GRCh38/hg38 |
NM_001130442 | chr11:g.533552C>G | c.351G>C | p.K117N | RefSeq | GRCh38/hg38 |
NM_001130442.2 | chr11:g.533552C>G | c.351G>C | p.K117N | RefSeq | GRCh38/hg38 |
NM_176795 | chr11:g.533552C>G | c.351G>C | p.K117N | RefSeq | GRCh38/hg38 |
NM_005343.3 | chr11:g.533552C>G | c.351G>C | p.K117N | RefSeq | GRCh38/hg38 |
NM_005343 | chr11:g.533552C>G | c.351G>C | p.K117N | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
HRAS K117N | head and neck squamous cell carcinoma | predicted - sensitive | Tipifarnib | Preclinical - Pdx | Actionable | In a preclinical study, a head and neck squamous cell carcinoma patient-derived xenograft (PDX) model harboring HRAS K117N was sensitive to treatment with Zarnestra (tipifarnib), demonstrating inhibition of tumor growth, decreased cell proliferation, and reduced Erk activity (PMID: 32727882). | 32727882 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
HRAS K117N | loss of function | MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan) |