Gene Variant Detail

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Gene PIK3CA
Variant E109del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA E109del results in the deletion of one amino acid of the Pik3ca protein at amino acid 109 (UniProt.org). E109del has been identified in sequencing studies (PMID: 26643573, PMID: 25850943, PMID: 24121792), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Mar 2020).
Associated Drug Resistance

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Transcript NM_006218
gDNA chr3:g.179199153_179199155delGAA
cDNA c.328_330delGAA
Protein p.E110delE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179199153_179199155delGAA c.328_330delGAA p.E110delE RefSeq GRCh38/hg38
NM_006218 chr3:g.179199153_179199155delGAA c.328_330delGAA p.E110delE RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199153_179199155delGAA c.328_330delGAA p.E110delE RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA E109del unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References