Gene Variant Detail

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Gene PIK3CA
Variant K111del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA K111del results in the deletion of one amino acid in the Pik3ca protein at amino acid 111 (UniProt.org). K111del has not been biochemically characterized, but is predicted to confer a gain of function on the Pik3ca protein as demonstrated by increased transformation ability in two different cell lines (PMID: 29533785).
Associated Drug Resistance

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Transcript NM_006218
gDNA chr3:g.179199157_179199159delAGA
cDNA c.332_334delAGA
Protein p.K111delK
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658 chr3:g.179199157_179199159delAGA c.332_334delAGA p.K111delK RefSeq GRCh38/hg38
NM_006218 chr3:g.179199157_179199159delAGA c.332_334delAGA p.K111delK RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199157_179199159delAGA c.332_334delAGA p.K111delK RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References