Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : email@example.com
|Gene Variant Descriptions||PTEN S385A does not lie within any known functional domains of the Pten protein (UniProt.org). The functional effect of S385A is conflicting as it demonstrates Pten protein stability, cell cycle arrest, and transcriptional activation of FKHR similar to wild-type Pten in culture (PMID: 10866658), however, demonstrates reduced phosphorylation and Pten protein stability (PMID: 11035045) and decreased ability to undergo phosphorylation by Ck2 in cell culture (PMID: 16107342), and demonstrates increased lipid phosphatase activity, but not enhanced catalytic activity via PIP2, and leads to increased nuclear and membrane localization in cell culture (PMID: 17565999, PMID: 16807353), and therefore, its effect on Pten protein function is unknown.|
|Associated Drug Resistance|
|Category Variants Paths||
PTEN mutant PTEN S385A
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|