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Gene ABL1
Variant A356T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ABL1 A356T (corresponds to A337T in the canonical isoform) lies within the protein kinase domain of the Abl1 protein (UniProt.org). A356T confers a gain of function to the Abl1 protein as demonstrated by increased phosphorylation of STAT5 and ABL1 and elevated total phosphotyrosine levels in cultured cells (PMID: 28288113).
Associated Drug Resistance
Category Variants Paths

ABL1 mutant ABL1 act mut ABL1 A356T

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Transcript NM_007313.3
gDNA chr9:g.130872961G>A
cDNA c.1066G>A
Protein p.A356T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_007313.3 chr9:g.130872961G>A c.1066G>A p.A356T RefSeq GRCh38/hg38
NM_007313.2 chr9:g.130872961G>A c.1066G>A p.A356T RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References