Gene Variant Detail

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Gene RET
Variant F612_C620del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET F612_C620del results in the deletion of nine amino acids in the extracellular domain of the Ret protein from amino acids 612 to 620 (UniProt.org). F612_C620del has been identified in sequencing studies (PMID: 25157968, PMID: 9587071), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jan 2020).
Associated Drug Resistance

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Transcript NM_020975
gDNA chr10:g.43113630_43113656del27
cDNA c.1834_1860del27
Protein p.F612_C620delFPEEEKCFC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38
NM_020975 chr10:g.43113630_43113656del27 c.1834_1860del27 p.F612_C620delFPEEEKCFC RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Protein Effect Treatment Approaches
RET F612_C620del unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References