Gene Variant Detail

Gene PDGFRA
Variant H845Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PDGFRA H845Y lies within the tyrosine kinase 2 domain of the Pdgfra protein (PMID: 24132921). H845Y results in increased Pdgfra autophosphorylation and is transforming in cell culture (PMID: 24132921).
Associated Drug Resistance

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Transcript NM_006206
gDNA chr4:g.54285934C>T
cDNA c.2533C>T
Protein p.H845Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005265743 chr4:g.54285934C>T c.2533C>T p.H845Y RefSeq GRCh38/hg38
NM_006206 chr4:g.54285934C>T c.2533C>T p.H845Y RefSeq GRCh38/hg38
XM_011534385 chr4:g.54285934C>T c.2533C>T p.H845Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PDGFRA H845Y gain of function PDGFR Inhibitor (Pan) PDGFR-alpha Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PDGFRA H845Y Advanced Solid Tumor sensitive Crenolanib Preclinical Actionable In a preclinical study, crenolanib inhibited Pdgfra phosphorylation in cells expressing PDGFRA H845Y in culture (PMID: 24132921). 24132921
PDGFRA H845Y Advanced Solid Tumor sensitive Imatinib Preclinical Actionable In a preclinical study, Gleevec (imatinib) inhibited Pdgfra phosphorylation in cells expressing PDGFRA H845Y in culture (PMID: 24132921). 24132921