Gene Variant Detail

Gene CTNNB1
Variant G38fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CTNNB1 G38fs results in a change in the amino acid sequence of the Ctnnb1 protein beginning at aa 38 of 781, likely resulting in a truncation of the functional protein (UniProt.org). Due to the loss of all known functional domains (UniProt.org), G38fs is predicted to lead to a loss of Ctnnb1 protein function.
Associated Drug Resistance

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Transcript NM_001098210
gDNA chr3:g.(41224623_41224624)
cDNA c.(112_111)
Protein p.G38fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001904 chr3:g.(41224623_41224624) c.(112_111) p.G38fs RefSeq GRCh38/hg38
NM_001098210 chr3:g.(41224623_41224624) c.(112_111) p.G38fs RefSeq GRCh38/hg38
XM_006712985 chr3:g.(41224623_41224624) c.(112_111) p.G38fs RefSeq GRCh38/hg38
XM_005264886 chr3:g.(41224623_41224624) c.(112_111) p.G38fs RefSeq GRCh38/hg38
XM_017005738 chr3:g.(41224623_41224624) c.(112_111) p.G38fs RefSeq GRCh38/hg38
NM_001098209 chr3:g.(41224623_41224624) c.(112_111) p.G38fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Molecular Profile Protein Effect Treatment Approaches
CTNNB1 G38fs loss of function - predicted
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References