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Gene PIK3CA
Variant R108del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA R108del results in the deletion of an amino acid in the p85 domain of the Pik3ca protein at amino acid 108 (PMID: 15016963). R108del has been identified in the scientific literature (PMID: 29181861, PMID: 30537512, PMID: 27161972), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA R108del

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Transcript NM_006218.4
gDNA chr3:g.179199147_179199149delCGT
cDNA c.322_324delCGT
Protein p.R108del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179199147_179199149delCGT c.322_324delCGT p.R108del RefSeq GRCh38/hg38
NM_006218 chr3:g.179199147_179199149delCGT c.322_324delCGT p.R108del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199147_179199149delCGT c.322_324delCGT p.R108del RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199147_179199149delCGT c.322_324delCGT p.R108del RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199147_179199149delCGT c.322_324delCGT p.R108del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199147_179199149delCGT c.322_324delCGT p.R108del RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199147_179199149delCGT c.322_324delCGT p.R108del RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199147_179199149delCGT c.322_324delCGT p.R108del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References