Gene Variant Detail

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Gene BRAF
Variant D449Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF D449Y does not lie within any known functional domains of the Braf protein (UniProt.org). D449Y results in decreased sensitivity of Braf homodimers to drug-mediated disruption, and activation of truncated Braf dimers comparable to the wild-type protein in an in vitro assay in combination with D448Y (PMID: 30559419), but has not been individually characterized and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF D449Y

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Transcript NM_004333.5
gDNA chr7:g.140781663C>A
cDNA c.1345G>T
Protein p.D449Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.5 chr7:g.140781663C>A c.1345G>T p.D449Y RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781663C>A c.1345G>T p.D449Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References