Gene Variant Detail

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Gene CDK12
Variant R197L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDK12 R197L does not lie within any known functional domains of the Cdk12 protein (UniProt.org). R197L has not been characterized in the scientific literature and therefore, its effect on Cdk12 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 R197L

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Transcript NM_016507.4
gDNA chr17:g.39462661G>T
cDNA c.590G>T
Protein p.R197L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047436267.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436284.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436291.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436285.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436290.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_005257456.4 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_005257456.5 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436281.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436292.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436253.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_017024753.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436283.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436282.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436263.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436264.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436280.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_017024753.3 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436286.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436262.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39462661G>T c.590G>T p.R197L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References