Gene Variant Detail

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Gene BRAF
Variant T119S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF T119S does not lie within any known functional domains of the Braf protein (UniProt.org). T119S has been shown to confer resistance to a novel AKT degrader in the context of BRAF V600E (PMID: 34301793), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Aug 2022).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF T119S

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Transcript NM_004333.5
gDNA chr7:g.140834757G>C
cDNA c.356C>G
Protein p.T119S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140834757G>C c.356C>G p.T119S RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140834757G>C c.356C>G p.T119S RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140834757G>C c.356C>G p.T119S RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140834757G>C c.356C>G p.T119S RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References