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Gene CTNNB1
Variant M553V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CTNNB1 M553V lies within ARM repeat 10 of the Ctnnb1 protein (UniProt.org). M553V has been identified in sequencing studies (PMID: 22653804), but has not been biochemically characterized and therefore, its effect on Ctnnb1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

CTNNB1 mutant CTNNB1 M553V

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Transcript NM_001098210.2
gDNA chr3:g.41234271A>G
cDNA c.1657A>G
Protein p.M553V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001098210 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_024453356.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_047447479.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_017005738 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
NM_001098209.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_047447477.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_047447481.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_017005738.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_024453358.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
NM_001098209 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
NM_001904.3 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_024453357.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_005264886 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
NM_001098210.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_047447480.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_047447483.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_024453356.2 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_017005738.2 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_006712985 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
NM_001098210.2 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_006712985.2 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_047447478.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
NM_001904 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
NM_001098209.2 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
NM_001904.4 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38
XM_006712985.1 chr3:g.41234271A>G c.1657A>G p.M553V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References