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|Gene Variant Descriptions||ALK T1151K lies within the protein kinase domain and inhibitor binding region of the Alk protein (UniProt.org). T1151K has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK fusions (PMID: 28676215, PMID: 30519133), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Jul 2022).|
|Associated Drug Resistance||Y|
|Category Variants Paths||
ALK mutant ALK T1151K
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|