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Gene KEAP1
Variant P455fs
Impact List frameshift
Protein Effect loss of function
Gene Variant Descriptions KEAP1 P455fs results in a change in the amino acid sequence of the Keap1 protein beginning at aa 455 of 624, likely resulting in premature truncation of the functional protein (UniProt.org). P455fs results in loss of Nfe2l2 inhibition leading to increased Nfe2l2 target gene and protein expression and increased cell survival following irradiation and hydrogen peroxide treatment in culture (PMID: 33071215).
Associated Drug Resistance
Category Variants Paths

KEAP1 mutant KEAP1 inact mut KEAP1 P455fs

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Transcript NM_203500.2
gDNA chr19:g.(10489816_10489817)
cDNA c.(1363_1362)
Protein p.P455fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_203500.2 chr19:g.(10489816_10489817) c.(1363_1362) p.P455fs RefSeq GRCh38/hg38
XM_005260173.1 chr19:g.(10489816_10489817) c.(1363_1362) p.P455fs RefSeq GRCh38/hg38
NM_203500.1 chr19:g.(10489816_10489817) c.(1363_1362) p.P455fs RefSeq GRCh38/hg38
NM_012289.4 chr19:g.(10489816_10489817) c.(1363_1362) p.P455fs RefSeq GRCh38/hg38
XM_005260174.1 chr19:g.(10489816_10489817) c.(1363_1362) p.P455fs RefSeq GRCh38/hg38
NM_012289.3 chr19:g.(10489816_10489817) c.(1363_1362) p.P455fs RefSeq GRCh38/hg38
XM_011528452.1 chr19:g.(10489816_10489817) c.(1363_1362) p.P455fs RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References