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Gene | KDR |
Variant | G873R |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | KDR (VEGFR2) G873R lies within the protein kinase domain of the Kdr (Vegfr2) protein (UniProt.org). G873R has been identified in sequencing studies (PMID: 26009992, PMID: 26295973, PMID: 16959974), but has not been biochemically characterized and therefore, its effect on Kdr (Vegfr2) protein function is unknown (PubMed, Feb 2021). |
Associated Drug Resistance |
Transcript | NM_002253.3 |
gDNA | chr4:g.55096340C>T |
cDNA | c.2617G>A |
Protein | p.G873R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002253 | chr4:g.55096340C>T | c.2617G>A | p.G873R | RefSeq | GRCh38/hg38 |
NM_002253.3 | chr4:g.55096340C>T | c.2617G>A | p.G873R | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
KDR G873R | unknown |