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Gene | KDR |
Variant | L1049W |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | KDR (VEGFR2) L1049W lies within the protein kinase domain of the Kdr (Vegfr2) protein (UniProt.org). L1049W has been identified in the scientific literature (PMID: 29588308), but has not been biochemically characterized and therefore, its effect on Kdr (Vegfr2) protein function is unknown (PubMed, Jan 2021). |
Associated Drug Resistance |
Transcript | NM_002253.3 |
gDNA | chr4:g.55090002A>C |
cDNA | c.3146T>G |
Protein | p.L1049W |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002253 | chr4:g.55090002A>C | c.3146T>G | p.L1049W | RefSeq | GRCh38/hg38 |
NM_002253.3 | chr4:g.55090002A>C | c.3146T>G | p.L1049W | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
KDR L1049W | unknown |