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|Gene Variant Descriptions||FGFR2 A553D lies within the protein kinase domain of the Ffgr2 protein (UniProt.org). A553D has been predicted to affect the protein stability of Fgfr2 by structural modeling (PMID: 32859654), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Apr 2022).|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF V600E FGFR2 A553D||lung non-small cell carcinoma||predicted - sensitive||Vemurafenib||Case Reports/Case Series||Actionable||In a clinical study, Zelboraf (vemurafenib) treatment resulted in stable disease for 3.3 months in a non-small cell lung cancer patient harboring BRAF V600E, tested in tissue and plasma, and FGFR2 A553D, tested in plasma only (PMID: 32859654).||32859654|