Gene Variant Detail

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Gene ROS1
Variant F2004L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 F2004L lies within the protein kinase domain of the Ros1 protein (UniProt.org). F2004L has been demonstrated to confer resistance to ALK inhibitors in the context of Ros1 fusions in culture (PMID: 33558279), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, May 2022).
Associated Drug Resistance Y

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Transcript NM_002944.2
gDNA chr6:g.117317268A>G
cDNA c.6010T>C
Protein p.F2004L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117317268A>G c.6010T>C p.F2004L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
ROS1 F2004L unknown